Gene information
Official symbol CALCA
Official full name calcitonin related polypeptide alpha
Gene type protein-coding gene
Chromosome11p15.2
Alias symbolCGRP|CGRP-alpha
Previous symbolCALC1
Gene familyNeuropeptides
Resources
Entrez Gene 796
HGNC HGNC:1437
Ensembl ENSG00000110680
Vega OTTHUMG00000159731
UCSC uc001mlt.2
GO terms: 81 records
GO Description Category LogP Number of genes Detail
GO:0001664 G protein-coupled receptor binding GO Molecular Functions -22.7408810 35 More
GO:0001934 positive regulation of protein phosphorylation GO Biological Processes -52.8272623 84 More
GO:0001976 nervous system process involved in regulation of systemic arterial blood pressure GO Biological Processes -4.91299256 6 More
GO:0003013 circulatory system process GO Biological Processes -65.2875605 130 More
GO:0003073 regulation of systemic arterial blood pressure GO Biological Processes -22.2238525 34 More
GO:0003085 negative regulation of systemic arterial blood pressure GO Biological Processes -9.78130162 11 More
GO:0005179 hormone activity GO Molecular Functions -33.3562443 33 More
GO:0006873 cellular ion homeostasis GO Biological Processes -10.3574947 26 More
GO:0006875 cellular metal ion homeostasis GO Biological Processes -10.3879696 23 More
GO:0006935 chemotaxis GO Biological Processes -33.1726887 55 More
GO:0006937 regulation of muscle contraction GO Biological Processes -20.8046481 43 More
GO:0006940 regulation of smooth muscle contraction GO Biological Processes -12.9613663 21 More
GO:0006954 inflammatory response GO Biological Processes -86.5569367 100 More
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO Biological Processes -9.16710904 33 More
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO Biological Processes -6.95524830 22 More
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO Biological Processes -11.6592522 24 More
GO:0007204 positive regulation of cytosolic calcium ion concentration GO Biological Processes -15.6883547 39 More
GO:0007565 female pregnancy GO Biological Processes -18.4002911 25 More
GO:0007566 embryo implantation GO Biological Processes -9.99023740 10 More
GO:0007568 aging GO Biological Processes -23.5429582 29 More
GO:0007610 behavior GO Biological Processes -18.1916656 76 More
GO:0008015 blood circulation GO Biological Processes -65.7270163 119 More
GO:0008016 regulation of heart contraction GO Biological Processes -27.6827716 55 More
GO:0008217 regulation of blood pressure GO Biological Processes -35.2019435 60 More
GO:0009266 response to temperature stimulus GO Biological Processes -12.1149168 32 More
GO:0019725 cellular homeostasis GO Biological Processes -21.1508273 85 More
GO:0030003 cellular cation homeostasis GO Biological Processes -9.22969208 24 More
GO:0030278 regulation of ossification GO Biological Processes -11.2759455 26 More
GO:0030279 negative regulation of ossification GO Biological Processes -7.69659659 12 More
GO:0030424 axon GO Cellular Components -6.14132550 54 More
GO:0030545 signaling receptor regulator activity GO Molecular Functions -87.4728446 102 More
GO:0030546 signaling receptor activator activity GO Molecular Functions -90.4065983 101 More
GO:0030595 leukocyte chemotaxis GO Biological Processes -30.6401488 33 More
GO:0032147 activation of protein kinase activity GO Biological Processes -11.6086663 28 More
GO:0033555 multicellular organismal response to stress GO Biological Processes -7.79385832 16 More
GO:0033674 positive regulation of kinase activity GO Biological Processes -29.8538991 87 More
GO:0034103 regulation of tissue remodeling GO Biological Processes -21.5631413 32 More
GO:0034104 negative regulation of tissue remodeling GO Biological Processes -6.91942497 9 More
GO:0034612 response to tumor necrosis factor GO Biological Processes -24.4651326 32 More
GO:0042330 taxis GO Biological Processes -33.0828571 55 More
GO:0043025 neuronal cell body GO Cellular Components -9.18558636 52 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0043679 axon terminus GO Cellular Components -2.06584249 11 More
GO:0044057 regulation of system process GO Biological Processes -61.6610386 136 More
GO:0044297 cell body GO Cellular Components -11.7206640 62 More
GO:0044306 neuron projection terminus GO Cellular Components -2.47884900 13 More
GO:0044703 multi-organism reproductive process GO Biological Processes -20.5752550 28 More
GO:0044706 multi-multicellular organism process GO Biological Processes -20.0155761 28 More
GO:0045124 regulation of bone resorption GO Biological Processes -6.02130395 7 More
GO:0045776 negative regulation of blood pressure GO Biological Processes -17.1357953 22 More
GO:0045859 regulation of protein kinase activity GO Biological Processes -34.3615088 109 More
GO:0045860 positive regulation of protein kinase activity GO Biological Processes -29.3929160 47 More
GO:0045932 negative regulation of muscle contraction GO Biological Processes -6.35549828 9 More
GO:0045986 negative regulation of smooth muscle contraction GO Biological Processes -5.72938190 7 More
GO:0046850 regulation of bone remodeling GO Biological Processes -7.11509809 13 More
GO:0048018 receptor ligand activity GO Molecular Functions -91.0736151 101 More
GO:0048265 response to pain GO Biological Processes -4.73205562 8 More
GO:0050801 ion homeostasis GO Biological Processes -12.0812968 60 More
GO:0050900 leukocyte migration GO Biological Processes -39.9164759 46 More
GO:0050951 sensory perception of temperature stimulus GO Biological Processes -3.21663541 6 More
GO:0051347 positive regulation of transferase activity GO Biological Processes -26.6059528 90 More
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway GO Biological Processes -4.39154198 8 More
GO:0055065 metal ion homeostasis GO Biological Processes -12.9426258 29 More
GO:0055074 calcium ion homeostasis GO Biological Processes -10.3600555 19 More
GO:0055080 cation homeostasis GO Biological Processes -11.5718912 30 More
GO:0055082 cellular chemical homeostasis GO Biological Processes -17.6289728 71 More
GO:0060326 cell chemotaxis GO Biological Processes -35.3882493 41 More
GO:0070848 response to growth factor GO Biological Processes -40.6139195 102 More
GO:0071345 cellular response to cytokine stimulus GO Biological Processes -39.647808 70 More
GO:0071356 cellular response to tumor necrosis factor GO Biological Processes -22.5666334 29 More
GO:0071363 cellular response to growth factor stimulus GO Biological Processes -39.8883675 98 More
GO:0072503 cellular divalent inorganic cation homeostasis GO Biological Processes -7.40235615 16 More
GO:0072507 divalent inorganic cation homeostasis GO Biological Processes -10.6286093 21 More
GO:0090257 regulation of muscle system process GO Biological Processes -33.9441291 67 More
GO:0097529 myeloid leukocyte migration GO Biological Processes -25.8454617 28 More
GO:0098771 inorganic ion homeostasis GO Biological Processes -12.1048319 31 More
GO:0098793 presynapse GO Cellular Components -4.56552653 42 More
GO:0150034 distal axon GO Cellular Components -2.90654836 23 More
GO:1903522 regulation of blood circulation GO Biological Processes -44.9821911 79 More
GO:1990089 response to nerve growth factor GO Biological Processes -1.87243811 6 More
GO:1990090 cellular response to nerve growth factor stimulus GO Biological Processes -1.96182882 6 More
KEGG pathways: 2 records
KEGG Description Category LogP Number of genes Detail
hsa04080 Neuroactive ligand-receptor interaction KEGG Pathway -22.6219922 65 More
hsa04270 Vascular smooth muscle contraction KEGG Pathway -11.6218936 17 More
Drug-Gene interaction
view
Related drugs: 21 records
Drug name Interaction type Source PMID View
amifampridine TTD view
amiodarone TTD view
andolast TTD view
azd7009 TTD view
azimilide TTD view
bimakalim TTD view
budiodarone TTD view
chembl1563246 TTD view
chembl42661 TTD view
cizolirtine TTD view
dalfampridine TTD view
diazoxide TTD view
dofetilide TTD view
dronedarone TTD view
eptinezumab antibodyinhibitor ChemblInteractions 25297013 view
ibutilide TTD view
minoxidil TTD view
nateglinide TTD view
pinacidil TTD view
prednisone NCI 11475715 view
ranitidine NCI 12495560 view
Related studies: 5 records
Molecular factor Omics type Application Objective MI type Reference
procalcitonin proteomics death[prognosis (bad)] acute myocardial infarction Kelly D et al. Biomarkers. 2010
procalcitonin proteomics major adverse cardiovascular events[prognosis (bad)] acute myocardial infarction Kelly D et al. Biomarkers. 2010
procalcitonin proteomics poor predictor myocardial infarction[diagnosis] myocardial infarction Bektas F et al. J Emerg Med. 2011
procalcitonin proteomics major adverse cardiovascular events[prognosis (bad)] acute ST elevation myocardial infarction Dai J et al. Scand J Clin Lab Invest. 2018
procalcitonin proteomics excellent predictor infectious disease[prognosis (bad)] acute myocardial infarction Vitkon-Barkay I et al. Am J Cardiol. 2018
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